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In depression...faith in deliverance, in ultimate restoration, is absent. The pain is unrelenting, and what makes the condition intolerable is the foreknowledge that no rememdy will come, not in a day, an hour, a month, or a minute. It is hopelessness even more than pain that crushes the soul.
-William Styron, from 'Darkness Visible; A Memoir of Madness', 1990